Murphy Lab - UC Davis
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IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor...

Sun, K Hsiao, Hh Li, M Erik Ames Bouchlaka, M Welniak, La Hagino, T Jagdeo, J Pai, Cc Chen, M ...

Published in The Journal of Immunology

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. It has been previously reported that lung GVHD severity directly correlates with the expansion of donor Th17 cells in the absence of IFN-γ. However, the consequence of Th17-associated lung GVHD in the presence of IFN-γ has not been well characterized...

Contrasting effects of anti-Ly49A due to MHC class I cis binding on NK cell-mediated allogeneic bone marrow cell resista...

Alvarez, M Sungur, Cm Erik Ames Anderson, Sk Pomeroy, C William Murphy

Published in The Journal of Immunology

NK subsets have activating and inhibitory receptors that bind MHC-I. Ly49A is a mouse inhibitory receptor that binds with high affinity to H2(d) in both a cis- and trans-manner. Ly49A cis-associations limit trans-interactions with H2(d)-expressing targets as well as mAb binding. We demonstrate that cis-interactions affect mAb effector functions. In...

Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death d...

Weiss, Jm Subleski, Jj Back, T Chen, X Watkins, Sk Yagita, H Sayers, Tj William Murphy Wiltrout, Rh

Published in The Journal of Immunology

Fas ligand expression in certain tumors has been proposed to contribute to immunosuppression and poor prognosis. However, immunotherapeutic approaches may elicit the Fas-mediated elimination of immunosuppressive regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) within tumors that represent major obstacles for cancer immunother...

NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype.

Erik Ames Canter, Rj Grossenbacher, Sk Mac, S Chen, M Smith, Rc Hagino, T Perez-Cunningham, J Gail Sckisel Urayama, S ...

Published in The Journal of Immunology

Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are able to target stem cells as shown by their ability to reject allogeneic hematopoietic stem cells but not solid tissue grafts. Using multiple preclinical models, inc...

Increased antitumor effects using IL-2 with anti-TGF-β reveals competition between mouse NK and CD8 T cells.

Alvarez, M Bouchlaka, Mn Gail Sckisel Sungur, Cm Chen, M William Murphy

Published in The Journal of Immunology

Because of increasing interest in the removal of immunosuppressive pathways in cancer, the combination of IL-2 with Abs to neutralize TGF-β, a potent immunosuppressive cytokine, was assessed. Combination immunotherapy resulted in significantly greater antitumor effects. These were correlated with significant increases in the numbers and functionali...

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