Sun, K Hsiao, Hh Li, M Erik Ames Bouchlaka, M Welniak, La Hagino, T Jagdeo, J Pai, Cc Chen, M
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Published in
The Journal of Immunology
Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. It has been previously reported that lung GVHD severity directly correlates with the expansion of donor Th17 cells in the absence of IFN-γ. However, the consequence of Th17-associated lung GVHD in the presence of IFN-γ has not been well characterized...
Alvarez, M Sungur, Cm Erik Ames Anderson, Sk Pomeroy, C William Murphy
Published in
The Journal of Immunology
NK subsets have activating and inhibitory receptors that bind MHC-I. Ly49A is a mouse inhibitory receptor that binds with high affinity to H2(d) in both a cis- and trans-manner. Ly49A cis-associations limit trans-interactions with H2(d)-expressing targets as well as mAb binding. We demonstrate that cis-interactions affect mAb effector functions. In...
Weiss, Jm Subleski, Jj Back, T Chen, X Watkins, Sk Yagita, H Sayers, Tj William Murphy Wiltrout, Rh
Published in
The Journal of Immunology
Fas ligand expression in certain tumors has been proposed to contribute to immunosuppression and poor prognosis. However, immunotherapeutic approaches may elicit the Fas-mediated elimination of immunosuppressive regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) within tumors that represent major obstacles for cancer immunother...
Erik Ames Canter, Rj Grossenbacher, Sk Mac, S Chen, M Smith, Rc Hagino, T Perez-Cunningham, J Gail Sckisel Urayama, S
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Published in
The Journal of Immunology
Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are able to target stem cells as shown by their ability to reject allogeneic hematopoietic stem cells but not solid tissue grafts. Using multiple preclinical models, inc...
Alvarez, M Bouchlaka, Mn Gail Sckisel Sungur, Cm Chen, M William Murphy
Published in
The Journal of Immunology
Because of increasing interest in the removal of immunosuppressive pathways in cancer, the combination of IL-2 with Abs to neutralize TGF-β, a potent immunosuppressive cytokine, was assessed. Combination immunotherapy resulted in significantly greater antitumor effects. These were correlated with significant increases in the numbers and functionali...
