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Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells.

Published in OncoImmunology

For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence indicates that efficient anticancer immune responses also rely on innate immunity. Tietze et al. have recently elucidated an antigen-nonspecific role for memory CD8(+) T cells in cytokine-based canc...

Enhanced targeting of stem-like solid tumor cells with radiation and natural killer cells.

Published in OncoImmunology

Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine m...

Published in OncoImmunology

Impact of aging in cancer immunotherapy: The importance of using accurate preclinical models.

Published in OncoImmunology

Cancer immunotherapy holds great promise, yet its efficacy and applicability can be hampered by the rise of systemic toxicities. We have recently shown that the lethal side effects of cancer immunotherapy are markedly exacerbated with aging. Blocking tumor necrosis factor α or macrophages can alleviate the systemic toxicity of immunotherapy while p...