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Reprint of: Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies. PDF available through Get Fulltext Research

Boeckh, Michael Murphy, William J Peggs, Karl S

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies. PDF available through Get Fulltext Research

Boeckh, Michael Murphy, William J Peggs, Karl S

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

The triterpenoid CDDO-Me promotes hematopoietic progenitor expansion and myelopoiesis in mice. PDF available through Get Fulltext Research

Ames, Erik Harouna, Salif Meyer, Colin Welniak, Lisbeth A Murphy, William J

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The synthetic triterpenoid CDDO-Me has been shown to directly inhibit the growth of myeloid leukemias and lends itself to a wide array of therapeutic indications, including inflammatory conditions, because of its inhibition of NF-κB. We have previously demonstrated protection from acute graft-versus-host disease after CDDO-Me administration in an a...

Reprint of: Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies. PDF available through Get Fulltext Research

Boeckh, M William Murphy Peggs, Ks

Published in Biology of Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleuk... PDF available through Get Fulltext Research

Pai, Chien-Chun Steven Hsiao, Hui-Hua Sun, Kai Chen, Mingyi Hagino, Takeshi Tellez, Joseph Mall, Christine Blazar, Bruce R Monjazeb, Arta Abedi, Mehrdad ...

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Bortezomib, a proteasome inhibitor capable of direct antitumor effects, has been shown to prevent acute graft-versus-host disease (GVHD) when administered in a short course immediately after bone marrow transplantation (BMT) in mice. However, when bortezomib is given continuously, CD4(+) T cell-mediated gastrointestinal tract damage increases GVHD ...

Blood stem cell transplantation in older patients.

William Murphy Artz, As Champlin, Re Koreth, J Longo, Dl Van Den Brink, Mr

Published in Biology of Blood and Marrow Transplantation

A serious dichotomy currently exists in hematopoietic stem cell transplantation (HSCT) and cancer research. Cancer is a disease that predominantly affects older people, yet there is a paucity of cancer research addressing the very unique needs of this population. Even basic biologic processes that exist in aging (decline in immune competency, incre...

NK cells--from bench to clinic. PDF available through Get Fulltext Research

Murphy, William J Parham, Peter Miller, Jeffrey S

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

After decades of mouse and human research, we now know that natural killer (NK) cells have unique properties including memory. Although initially described as major histocompatibility complex (MHC) unrestricted killers, NK cells have several families of receptors that directly recognize MHC including Ly49 receptors in the mouse and killer immunoglo...

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