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Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcom... PDF available through Get Fulltext Research

Canter, Robert J Ames, Erik Mac, Stephanie Grossenbacher, Steven K Chen, Mingyi Li, Chin-Shang Borys, Dariusz Smith, Rachel C Tellez, Joe Sayers, Thomas J ...

Published in BMC Cancer

BackgroundIncreasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs would have differential effects on CSC populations depending on...

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