Murphy Lab - UC Davis
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News 66 Publications 5 Members

CpG expedites regression of local and systemic tumors when combined with activatable nanodelivery.

Kheirolomoom, A Ingham, Es Mahakian, Lm Tam, Sm Silvestrini, Mt Tumbale, Sk Foiret, J Hubbard, Ne Borowsky, Ad William Murphy ...

Published in Journal of Controlled Release

Ultrasonic activation of nanoparticles provides the opportunity to deliver a large fraction of the injected dose to insonified tumors and produce a complete local response. Here, we evaluate whether the local and systemic response to chemotherapy can be enhanced by combining such a therapy with locally-administered CpG as an immune adjuvant. In ord...

Reprint of: Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies.

Boeckh, M William Murphy Peggs, Ks

Published in Biology of Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

Contrasting effects of anti-Ly49A due to MHC class I cis binding on NK cell-mediated allogeneic bone marrow cell resista...

Alvarez, M Sungur, Cm Erik Ames Anderson, Sk Pomeroy, C William Murphy

Published in The Journal of Immunology

NK subsets have activating and inhibitory receptors that bind MHC-I. Ly49A is a mouse inhibitory receptor that binds with high affinity to H2(d) in both a cis- and trans-manner. Ly49A cis-associations limit trans-interactions with H2(d)-expressing targets as well as mAb binding. We demonstrate that cis-interactions affect mAb effector functions. In...

Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death d...

Weiss, Jm Subleski, Jj Back, T Chen, X Watkins, Sk Yagita, H Sayers, Tj William Murphy Wiltrout, Rh

Published in The Journal of Immunology

Fas ligand expression in certain tumors has been proposed to contribute to immunosuppression and poor prognosis. However, immunotherapeutic approaches may elicit the Fas-mediated elimination of immunosuppressive regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) within tumors that represent major obstacles for cancer immunother...

Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleuk...

Pai, Cc Hsiao, Hh Sun, K Chen, M Hagino, T Tellez, J Mall, C Blazar, Br Monjazeb, A Abedi, M ...

Published in Biology of Blood and Marrow Transplantation

Bortezomib, a proteasome inhibitor capable of direct antitumor effects, has been shown to prevent acute graft-versus-host disease (GVHD) when administered in a short course immediately after bone marrow transplantation (BMT) in mice. However, when bortezomib is given continuously, CD4(+) T cell-mediated gastrointestinal tract damage increases GVHD ...

Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immun...

Tietze, Jk Wilkins, De Gail Sckisel Bouchlaka, Mn Alderson, Kl Weiss, Jm Erik Ames Bruhn, Kw Craft, N Wiltrout, Rh ...

Published in Blood

Memory T cells exhibit tremendous antigen specificity within the immune system and accumulate with age. Our studies reveal an antigen-independent expansion of memory, but not naive, CD8(+) T cells after several immunotherapeutic regimens for cancer resulting in a distinctive phenotype. Signaling through T-cell receptors (TCRs) or CD3 in both mouse ...

Immunoediting and antigen loss: overcoming the achilles heel of immunotherapy with antigen non-specific therapies.

Monjazeb, Am Zamora, Ae Grossenbacher, Sk Mirsoian, A Gail Sckisel William Murphy

Published in Frontiers in Oncology

Cancer immunotherapy has emerged as a mainstream therapy option in the battle against cancer. Pre-clinical data demonstrates the ability of immunotherapy to harness the immune system to fight disseminated malignancy. Clinical translation has failed to recapitulate the promising results of pre-clinical studies although there have been some successes...

Influenza infection results in local expansion of memory CD8(+) T cells with antigen non-specific phenotype and function...

Gail Sckisel Tietze, Jk Zamora, Ae Hsiao, Hh Priest, So Wilkins, De Lanier, Ll Blazar, Br Baumgarth, N William Murphy ...

Published in Clinical & Experimental Immunology

Primary viral infections induce activation of CD8(+) T cells responsible for effective resistance. We sought to characterize the nature of the CD8(+) T cell expansion observed after primary viral infection with influenza. Infection of naive mice with different strains of influenza resulted in the rapid expansion of memory CD8(+) T cells exhibiting ...

Murine natural killer cell licensing and regulation by T regulatory cells in viral responses.

Sungur, Cm Tang-Feldman, Yj Erik Ames Alvarez, M Chen, M Longo, Dl Pomeroy, C William Murphy

Published in Proceedings of the National Academy of Sciences

Natural killer (NK) cells show differential functionality based on their capability of binding to self-MHC consistent with licensing. Here we show in vivo confirmation of the physiologic effects of licensing with differential effects of NK subsets on anti-murine cytomegalovirus (anti-MCMV) responses after syngeneic hematopoietic stem cell transplan...

NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype.

Erik Ames Canter, Rj Grossenbacher, Sk Mac, S Chen, M Smith, Rc Hagino, T Perez-Cunningham, J Gail Sckisel Urayama, S ...

Published in The Journal of Immunology

Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are able to target stem cells as shown by their ability to reject allogeneic hematopoietic stem cells but not solid tissue grafts. Using multiple preclinical models, inc...

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