Murphy Lab - UC Davis
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News 66 Publications 5 Members

The path(way) less traveled.

Abedi, M William Murphy

Published in Blood

In this issue of Blood, Mathewson et al characterized targeting a novel intracellular pathway with an agent known to induce potent antitumor effects but now also appears to potently suppress inflammatory responses by dendritic cells (DCs) and prevent graft-vs-host disease (GVHD). Identifying agents that can suppress GVHD yet not compromise graft-vs...

The authors reply.

Erik Ames William Murphy

Published in Transplantation Journal

Immunoregulatory pathways following strong inflammatory processes markedly impair CD4+ T cell responses.

Minnar, Cm William Murphy

Published in Human Vaccines & Immunotherapeutics

Attenuated age-impact on systemic inflammatory markers in the presence of a metabolic burden.

Erdembileg, A Mirsoian, A Enkhmaa, B Zhang, W Beckett, La William Murphy Berglund, Lf

Published in PLoS ONE

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5 dependent manner....

Mcdonald-Hyman, C Flynn, R Panoskaltsis-Mortari, A Peterson, N Macdonald, Kp Hill, Gr Luznik, L Serody, Js William Murphy Maillard, I ...

Published in Blood

Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication.

Montague, Mj Li, G Gandolfi, B Khan, R Aken, Bl Searle, Sm Minx, P Hillier, Lw Koboldt, Dc Davis, Bw ...

Published in Proceedings of the National Academy of Sciences

Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for...

Resveratrol Prevents High Fluence Red Light-Emitting Diode Reactive Oxygen Species-Mediated Photoinhibition of Human Ski...

Mamalis, A Koo, E Isseroff, Rr William Murphy Jagdeo, J

Published in PLoS ONE

IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor...

Sun, K Hsiao, Hh Li, M Erik Ames Bouchlaka, M Welniak, La Hagino, T Jagdeo, J Pai, Cc Chen, M ...

Published in The Journal of Immunology

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. It has been previously reported that lung GVHD severity directly correlates with the expansion of donor Th17 cells in the absence of IFN-γ. However, the consequence of Th17-associated lung GVHD in the presence of IFN-γ has not been well characterized...

Natural killer cell subsets differentially reject embryonic stem cells based on licensing.

Perez-Cunningham, J Erik Ames Smith, Rc Peter, Ak Naidu, R Nolta, Ja William Murphy

Published in Transplantation Journal

Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells.

Gail Sckisel William Murphy

Published in OncoImmunology

For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence indicates that efficient anticancer immune responses also rely on innate immunity. Tietze et al. have recently elucidated an antigen-nonspecific role for memory CD8(+) T cells in cytokine-based canc...

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