Murphy Lab - UC Davis
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News 66 Publications 5 Members

Models to Study NK Cell Biology and Possible Clinical Application.

Zamora, Anthony E Grossenbacher, Steven K Aguilar, Ethan G Murphy, William J

Published in Current protocols in immunology

Natural killer (NK) cells are large granular lymphocytes of the innate immune system, responsible for direct targeting and killing of both virally infected and transformed cells. NK cells rapidly recognize and respond to abnormal cells in the absence of prior sensitization due to their wide array of germline-encoded inhibitory and activating recept...

Reprint of: Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies.

Boeckh, Michael Murphy, William J Peggs, Karl S

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies.

Boeckh, Michael Murphy, William J Peggs, Karl S

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The 2015 Tandem American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplant Meetings provide an opportunity to review the current status and future perspectives on therapy for cytomegalovirus (CMV) infection in the setting of hematopoietic stem cell transplantation (HSCT). After many years during which...

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice...

Mirsoian, Annie Bouchlaka, Myriam N Sckisel, Gail D Chen, Mingyi Pai, Chien-Chun Steven Maverakis, Emanuel Spencer, Richard G Fishbein, Kenneth W Siddiqui, Sana Monjazeb, Arta M ...

Published in The Journal of experimental medicine

Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm. We found that aging was accompanied by increases in visceral fat similar to that seen in young obese (ob/ob or diet-induced obese [DIO]) ...

Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcom...

Canter, Robert J Ames, Erik Mac, Stephanie Grossenbacher, Steven K Chen, Mingyi Li, Chin-Shang Borys, Dariusz Smith, Rachel C Tellez, Joe Sayers, Thomas J ...

Published in BMC Cancer

BackgroundIncreasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs would have differential effects on CSC populations depending on...

Treatment of chronic graft-versus-host disease with bortezomib.

Pai, Chien-Chun Steven Chen, Mingyi Mirsoian, Annie Grossenbacher, Steven K Tellez, Joseph Ames, Erik Sun, Kai Jagdeo, Jared Blazar, Bruce R Murphy, William J ...

Published in Blood

Chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) has emerged as a predominant complication following HSCT and has a distinct etiology. We and others have previously demonstrated that bortezomib, a proteasome inhibitor, can prevent but not treat acute GVHD in mice. To assess the effects of...

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans.

Flynn, Ryan Du, Jing Veenstra, Rachelle G Reichenbach, Dawn K Panoskaltsis-Mortari, Angela Taylor, Patricia A Freeman, Gordon J Serody, Jonathan S Murphy, William J Munn, David H ...

Published in Blood

Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorgan system cGVHD and associated bronchiolitis obliterans syndrome (BOS) in a murine model, we hypothe...

Bystander activation and anti-tumor effects of CD8+ T cells following Interleukin-2 based immunotherapy is independent o...

Monjazeb, Arta M Tietze, Julia K Grossenbacher, Steven K Hsiao, Hui-Hua Zamora, Anthony E Mirsoian, Annie Koehn, Brent Blazar, Bruce R Weiss, Jonathan M Wiltrout, Robert H ...

Published in PloS one

We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells displaying a CD25(-)NKG2D(+) phenotype in a cytokine dependent manner, which were responsible for the a...

Advantages and clinical applications of natural killer cells in cancer immunotherapy

Ames, Erik Murphy, William J.

Published in Cancer Immunology, Immunotherapy

The past decade has witnessed a burgeoning of research and further insight into the biology and clinical applications of natural killer (NK) cells. Once thought to be simple innate cells important only as cytotoxic effector cells, our understanding of NK cells has grown to include memory-like responses, the guidance of adaptive responses, tissue re...

The triterpenoid CDDO-Me promotes hematopoietic progenitor expansion and myelopoiesis in mice.

Ames, Erik Harouna, Salif Meyer, Colin Welniak, Lisbeth A Murphy, William J

Published in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

The synthetic triterpenoid CDDO-Me has been shown to directly inhibit the growth of myeloid leukemias and lends itself to a wide array of therapeutic indications, including inflammatory conditions, because of its inhibition of NF-κB. We have previously demonstrated protection from acute graft-versus-host disease after CDDO-Me administration in an a...

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