Murphy Lab - UC Davis
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News 66 Publications 5 Members

A High-Resolution SNP Array-Based Linkage Map Anchors a New Domestic Cat Draft Genome Assembly and Provides Detailed Pat...

Li, Gang Hillier, LaDeana W Grahn, Robert A Zimin, Aleksey V David, Victor A Menotti-Raymond, Marilyn Middleton, Rondo Hannah, Steven Hendrickson, Sher Makunin, Alex ...

Published in G3 (Bethesda, Md.)

High-resolution genetic and physical maps are invaluable tools for building accurate genome assemblies, and interpreting results of genome-wide association studies (GWAS). Previous genetic and physical maps anchored good quality draft assemblies of the domestic cat genome, enabling the discovery of numerous genes underlying hereditary disease and p...

High fluence light emitting diode-generated red light modulates characteristics associated with skin fibrosis.

A, Mamalis E, Koo M, Garcha William Murphy Rr, Isseroff J, Jagdeo

Published in Journal of Biophotonics

Skin fibrosis, often referred to as skin scarring, is a significant international health problem with limited treatment options. The hallmarks of skin fibrosis are increased fibroblast proliferation, collagen production, and migration speed. Recently published clinical observations indicate that visible red light may improve skin fibrosis. In this ...

Preclinical modeling of hematopoietic stem cell transplantation - advantages and limitations.

Stolfi, Jessica L Pai, Chien-Chun S Murphy, William J

Published in The FEBS journal

Hematopoietic stem cell transplantation, which was first successfully performed in the 1950s, remains a critical therapeutic modality for treatment of a diverse array of diseases, including a multitude of hematological malignancies, autoimmune disorders, amyloidosis and inherited genetic hematological disorders. Although great advances have been ma...

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism...

Flynn, Ryan Paz, Katelyn Du, Jing Reichenbach, Dawn K Taylor, Patricia A Panoskaltsis-Mortari, Angela Vulic, Ante Luznik, Leo MacDonald, Kelli K P Hill, Geoffrey R ...

Published in Blood

Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is dependent on assessment in preclinical murine models of cGVHD. Rho-associated kinase 2 (ROCK2) recently was shown to be implicated in regulation of interleukin-21 (IL-21) and IL-17 sec...

Natural killer cell immunotherapy to target stem-like tumor cells

Grossenbacher, Steven K. Canter, Robert J. Murphy, William J.

Published in Journal for ImmunoTherapy of Cancer

Advances in cancer immunotherapy are leading to its increasing and successful application for the treatment of solid–tissue cancers. Despite the recent advances there are still significant barriers, in particular, evidence for significant tumor heterogeneity, both genetic and epigenetic that limit long-term efficacy. Subpopulations of “stem-like” t...

Mouse host unlicensed NK cells promote donor allogeneic bone marrow engraftment.

Alvarez, Maite Sun, Kai Murphy, William J

Published in Blood

Natural killer (NK) cells exist as subsets based on expression of inhibitory receptors that recognize major histocompatibility complex I (MHCI) molecules. NK cell subsets bearing MHCI binding receptors for self-MHCI have been termed as "licensed" and exhibit a higher ability to respond to stimuli. In the context of bone marrow transplantation (BMT)...

Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats.

Arzi, Boaz Mills-Ko, Emily Verstraete, Frank J M Kol, Amir Walker, Naomi J Badgley, Megan R Fazel, Nasim Murphy, William J Vapniarsky, Natalia Borjesson, Dori L ...

Published in Stem cells translational medicine

This study is the first to demonstrate the safety and efficacy of fresh, autologous, adipose-derived stem cell systemic therapy for a naturally occurring, chronic inflammatory disease in cats. The findings demonstrate that this therapy resulted in complete clinical and histological resolution or reduction in clinical disease severity and immune mod...

Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity.

Shanker, Anil Pellom, Samuel T Jr Dudimah, Duafalia F Thounaojam, Menaka C de Kluyver, Rachel L Brooks, Alan D Yagita, Hideo McVicar, Daniel W Murphy, William J Longo, Dan L ...

Published in Cancer research

Cancer immunotherapy shows great promise but many patients fail to show objective responses, including in cancers that can respond well, such as melanoma and renal adenocarcinoma. The proteasome inhibitor bortezomib sensitizes solid tumors to apoptosis in response to TNF-family death ligands. Because T cells provide multiple death ligands at the tu...

Late administration of murine CTLA-4 blockade prolongs CD8-mediated anti-tumor effects following stimulatory cancer immu...

Sckisel, Gail D. Mirsoian, Annie Bouchlaka, Myriam N. Tietze, Julia K. Chen, Mingyi Blazar, Bruce R. Murphy, William J.

Published in Cancer Immunology, Immunotherapy

We have demonstrated that immunostimulatory therapies such as interleukin-2 (IL-2) and anti-CD40 (αCD40) can be combined to deliver synergistic anti-tumor effects. While this strategy has shown success, efficacy varies depending on a number of factors including tumor type and severe toxicities can be seen. We sought to determine whether blockade of...

Resveratrol Prevents High Fluence Red Light-Emitting Diode Reactive Oxygen Species-Mediated Photoinhibition of Human Ski...

A, Mamalis E, Koo Rr, Isseroff William Murphy J, Jagdeo

Published in PLoS ONE

Background: Skin fibrosis is a significant medical problem that leads to a functional, aesthetic, and psychosocial impact on quality-of-life. Light-emitting diode-generated 633-nm red light (LED-RL) is part of the visible light spectrum that is not known to cause DNA damage and is considered a safe, non-invasive, inexpensive, and portable potential...

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